Platelet Heterogeneity
نویسندگان
چکیده
منابع مشابه
Biology of Platelet Purinergic Receptors and Implications for Platelet Heterogeneity
Platelets are small anucleated cells present only in mammals. Platelets mediate intravascular hemostatic balance, prevent interstitial bleeding, and have a major role in thrombosis. Activation of platelet purinergic receptors is instrumental in initiation of hemostasis and formation of the hemostatic plug, although this activation process becomes problematic in pathological settings of thrombos...
متن کاملPlatelet heterogeneity: variation in coagulation complexes on platelet subpopulations.
OBJECTIVE Previous work has shown that platelets stimulated with the combination of thrombin and convulxin, a glycoprotein VI agonist, develop 2 populations with different levels of alpha-granule factor V bound to the platelet surface. To evaluate whether this phenomenon is restricted to alpha-granule components or is a feature that can be generalized to other coagulation factors, we studied th...
متن کاملPlatelet response heterogeneity in thrombus formation.
Vascular injury leads to formation of a structured thrombus as a consequence of platelet activation and aggregation, thrombin and fibrin formation, and trapping of leukocytes and red cells. This review summarises current evidence for heterogeneity of platelet responses and functions in the thrombus-forming process. Environmental factors contribute to response heterogeneity, as the platelets in ...
متن کاملHeterogeneity of Human Whole Blood Platelet Subpopulations
A quantitative high yield method utilizing isosmotic arabino-galactan (Stractan) solutions and isopycnic centrifugation was developed to isolate and to fractionate total human platelet populations into density-dependent subpopulations. Isolated platelets were free of factor VIll/von Willebrand factor and other plasma proteins. They responded to ADP, epinephrine, and collagen with a sensitivity ...
متن کاملHeterogeneity of Human Whole Blood Platelet
A quantitative high yield method utilizing isosmotic arabino-galactan (Stractan) solutions and isopycnic centrifugation was developed to isolate and to fractionate total human platelet populations into density-dependent subpopulations. Isolated platelets were free of factor VIll/von Willebrand factor and other plasma proteins. They responded to ADP, epinephrine, and collagen with a sensitivity ...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2005
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000155987.26583.9b